Endocrine Abstracts

Hydrocortisone reveals its action by activation of transcription of specific genes that is achieved by binding of hormones nuclear receptors (NRs) to cognate sites on DNA and recruiting coactivators of basal transcription machinery. NRs are able to overcome restricting conformation of chromatin by altering chromatin-remodeling machinery (chromatin-remodeling protein complexes, histone and nonhistone modifying enzymes). However, a possibility arise that genomic DNA accessibilit...

Decondensation of chromatin and the pattern of its packaging in eukariotic nuclei underlie gene expression. It should be outlined that both features are determined not only by the main components of chromatin and nuclear matrix, but also by loosely bound molecules, such as phospholipids, which can interact with nucleoproteins and maintain the degree of chromatin condensation.The steroid hormone estradiol induced changes both of total phospholipid and ind...

Decondensation of chromatin and the pattern of its packaging in eukariotic nuclei underlie gene expression. It should be outlined that both features are determined not only by the main components of chromatin and nuclear matrix, but also by loosely bound molecules, such as phospholipids, which can interact with nucleoproteins and maintain the degree of chromatin condensation.The steroid hormone estradiol induced changes both of total phospholipid and ind...